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PRINCIPLE trial

This page shows the latest PRINCIPLE trial news and features for those working in and with pharma, biotech and healthcare.

Oxford University to study antiparasitic drug ivermectin in COVID-19 trial

Oxford University to study antiparasitic drug ivermectin in COVID-19 trial

The potential COVID-19 treatment will be investigated as part of the large-scale PRINCIPLE trial. ... Earlier this year, the antiviral treatment favipiravir was also added to the PRINCIPLE trial as a possible at-home therapy for COVID-19.

Latest news

  • UK study finds antibiotics azithromycin and doxycycline ineffective against COVID-19 UK study finds antibiotics azithromycin and doxycycline ineffective against COVID-19

    The PRINCIPLE trial shows that doxycycline is not effective as a treatment for suspected COVID-19 in the absence of bacterial pneumonia, and should not be used in this way,” the ... COVID-19 is not helpful,” said Simon de Lusignan, director of RCGP

  • Novo Nordisk’s semaglutide obesity trial hits the mark Novo Nordisk’s semaglutide obesity trial hits the mark

    Novo Nordisk’s run of good news with GLP-1 agonist semaglutide has continued with a mid-stage trial showing it can achieve significant weight loss in adults with obesity. ... The proof-of-principle trial showed that daily, subcutaneous injections of

  • Study finds no problems switching from Remicade to biosimilar Study finds no problems switching from Remicade to biosimilar

    The comparative trial - called NOR-SWITCH - was presented at the 2016 UEG Week in Vienna, Austria and showed that swapping from Remicade to a biosimilar version made by Celltrion posed no ... principle investigator in the trial which was sponsored by the

  • Malaria vaccine gives Malaria vaccine gives "unprecedented" results

    In this trial, we showed in principle that sporozoites can be developed into a malaria vaccine that confers high levels of protection and is made using the good manufacturing practices that ... are required for vaccine licensure," said the trial's

  • Merck's Zolinza clears phase III trial in multiple myeloma

    Merck &Co's Zolinza has shown promise in a phase III trial involving multiple myeloma patients, potentially opening up a lucrative new market for the drug. ... In the phase III trial, Zolinza given in combination with Takeda/Millennium Pharmaceuticals'

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  • Clinical trials and the diversity principle

    CNBC he would rather take an extra week – if it meant having a more diverse trial population. ... The first was that, even in the face of a novel virus that disproportionately affects minority groups, it remains very difficult to recruit a diverse

  • September 2020: diversity and inclusion in clinical trials round-up September 2020: diversity and inclusion in clinical trials round-up

    A new focus on recruiting ethnic minority patients for a major COVID-19 trial. ... To increase the recruitment of Black and Asian people, and those from other minority ethnic groups, a pharmacist, Mahendra Patel, has joined the PRINCIPLE trial in a new

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