This page shows the latest tivantinib news and features for those working in and with pharma, biotech and healthcare.
ArQule and Kyowa Hakko abandoned their MET inhibitor tivantinib in 2017 after a string of trial failures, while GlaxoSmithKline/Exelixis’ also seem to have dropped their MET/VEGF inhibitor foretinib and
trials, with recent fails including c-MET inhibitor tivantinib.
Daiichi Sankyo is looking to new products such as novel oral anticoagulant (NOAC) Lixiana (edoxaban) - as well as pipeline candidates like tivantinib for liver cancer, quizartinib for leukaemia and mirogabalin for
These include tivantinib for liver cancer - tipped by some analysts as a $600m product despite disappointing data in lung cancer - quizartinib for leukaemia and mirogabalin for fibromyalgia.
It remains to be seen whether the failed study has implications for other c-MET inhibitors in clinical trials, although the class has had other notable casualties, including ArQule's tivantinib
Tivantinib is a first in-class inhibitor of MET, a receptor tyrosine kinase thought to play a role in the development of a number of human cancers. ... to proceed with further clinical development of tivantinib in this tumour type ". 14th January 2013.
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