Please login to the form below

Not currently logged in
Email:
Password:

BMS launches hepatitis C pill Daklinza in the UK

Will be offered as a combination treatment with Gilead's Solvadi

BMS Daklinza daclatasvir hepatitis C

Bristol-Myers Squibb has launched Daklinza (daclatasvir) in the UK just days after the hepatitis C pill was granted European approval.

The drug has a European licence for use in combination with Gilead's hugely successful Sovaldi (sofosbuvir) as an all-oral, once-daily regimen for the hepatitis C virus.

Charles Gore, chief executive of The Hepatitis C Trust, said: “With only 3% of people with hepatitis C in England accessing treatment each year, we are delighted by the announcement as it is crucial patients are able to access new treatments as early as possible so they have the opportunity to get cured of this cancer-causing virus.”

Daklinza is a first-in-class NS5A inhibitor that works across multiple genotypes as an oral once-daily treatment for the majority of patients with chronic hepatitis C.

One of its major benefits is that it does not need to be used with interferon alpha therapy, the current standard course of treatment that has possible side effects including depression, insomnia and flu-like symptoms.

Johanna Mercier, general manager of Bristol-Myers Squibb UK and Ireland, noted: “Study results have highlighted that daclatasvir has the potential to offer high cure rates, notably offering some of its most successful results in genotypes 1 and 3, which account for 90% of all hepatitis C cases in the UK.

In clinical trials, different daclatasvir-based combinations have shown promising cure rates for patients. Up to 98% of patients with genotype 1 and around 89% with genotype 3 showed positive clinical results when combining the pill with Sovaldi (sofosbuvir).

Data published in the NEJM earlier this year supporting the submission also included results from combining daclatasvir with interferon-alpha and ribavirin. After 12 weeks of treatment, 100% of patients with genotype 4 achieved sustained virologic response (SVR).

In January 2014, the European Medicines Agency (EMA) brought daclatasvir forward for priority review after recognising the need that exists for hepatitis C patients.

Daklinza forms the lynchpin of Bristol-Myers Squibb's hepatitis C aspirations and its Sovaldi combination continues to be investigated as a treatment for patients with high unmet needs in hepatitis C.

Article by
Kirstie Pickering

3rd September 2014

From: Sales

Share

Tags

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Anatomy Health

We are a health information design consultancy focused on developing simple, accessible and inclusive patient communications. From evaluating existing patient...

Latest intelligence

PM Society Digital Awards – the power of together
Our chief executive, Emma Statham, writes about the value of awards and the power of together....
Seduction_feature_image_thumb.jpg
Seduce anyone in four simple steps
You know the health of the global economy is dependent on our ability to seduce one another – don’t you? And you know that we need to be able to...
What Would Jeremy Do? : Assessing the impact of a Corbyn-led Labour government
GK Strategy are delighted to announce the launch our latest briefing paper entitled ‘What Would Jeremy Do? Assessing the impact of a Corbyn-led Labour government’....

Infographics