Please login to the form below

Not currently logged in
Email:
Password:

More data backs Novartis' serelaxin in heart failure

European Society of Cardiology (ESC) meeting told of significant additional benefits

Novartis 

Momentum continues to build behind Novartis' heart failure candidate serelaxin, with new data from the European Society of Cardiology (ESC) meeting cementing its position as a blockbuster-in-waiting.

A new analysis of data from the RELAX-AHF study has shown that it can provide significant additional benefits on heart failure symptoms and mortality when added to current therapy.

Six-month data from the trial showed that the recombinant relaxin-2 treatment - also known as RLX030 - reduced dyspnoea (shortness of breath) and death rates across all subgroups of patients tested, although Novartis cautioned that "the small numbers of patients in each group limit the statistical conclusions that can be drawn".

Relaxin is the hormone that modulates the cardiovascular responses during pregnancy by increasing vasodilation and renal function. It also seems to boost kidney function and cardiac output.

The RELAX-AHF data was one of the highlights of last year's cardiology calendar, with clinicians excited by the prospect of the first new treatment for acute heart failure in more than two decades. Data presented at the time showed that serelaxin reduced the risk of death by 37 per cent compared with conventional treatment at six months.

Since then, Novartis has submitted serelaxin for approval with regulatory agencies around the world, and the US FDA has designated the drug a 'breakthrough' therapy. Breakthrough designation means that Novartis will have a higher level of contact with the FDA during the review process, which should also be shorter.

"With RLX030 Novartis aims to bring the first therapy shown to improve longer-term outcomes to patients," said David Epstein, division head of Novartis Pharmaceuticals. 

The results suggest that treatment with serelaxin "is key to halting the downward spiral of organ damage that occurs during an AHF episode".

Almost a quarter of those who are hospitalised with AHF die within a year, and if approved serelaxin is expected to reach around $600m in annual sales within three years of launch and more than $1bn a year at peak.

Article by
Phil Taylor

3rd September 2013

From: Research

Share

Tags

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Four MSA

Four MSA creates world class integrated media solutions with global reach, deep insight, innovative methods and a highly personal approach....

Latest intelligence

If you needed an organ transplant, would you have one?
Lauren Packer discusses the worsening problem in the UK with an imbalance between the number of organs needed, and the number of those being donated....
Why tugging at our heartstrings is no longer enough to make us open our purses
Charlotte Shyllon (Director and Partner) and Maren Thurow (Senior Account Executive), discuss the highly emotive Make a Child Cry campaign video from Doctors of the World (Médecins du Monde)....
quantify_messages.png
Exploring full potential of e-detailing data
Today’s high quality e-detailing data can create better quality conversations with healthcare professionals and result in improved access and relationships....

Infographics